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Linagliptin combination with an SGLT2 inhibitor The first line therapy for management of glycemia for T2DM throughout the world is metformin [203]

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Start at the lower end of the dose range if you are also taking diuretics

Importantly, SCFAs can cross the BBB via monocarboxylate transporters located on endothelial cells and influence BBB integrity by upregulating the expression of tight junction proteins [186] and thereby potentially exert direct effects on microglia